Kyushu University researchers identify molecule to combat muscle aging

The study, published July 24, 2026, in Scientific Reports, focuses on hepatocyte growth factor (HGF). This protein acts as a signal for muscle stem cells to repair tissue after injury. Researchers led by Professor Ryuichi Tatsumi previously established that aging causes HGF to undergo nitration, a chemical process that impairs its ability to bind to muscle cells. By testing sulfur-based compounds, the team found that LASSS effectively blocks this damage, creating what they describe as "Super HGF."

In laboratory trials, LASSS more than doubled the binding efficiency of the protein to its receptors. Follow-up experiments on mice suffering from muscle wasting demonstrated that the treatment significantly reduced protein damage in living tissue. Professor Tatsumi noted that the compound does more than simply neutralize oxidants; it appears to structurally modify HGF to enhance its regenerative capacity. While clinical applications remain in the future, the findings offer a potential pathway to treat muscle loss linked to prolonged inactivity or the natural aging process, with potential benefits extending to veterinary care for companion animals.